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Resilience and Ecolab Advancing Biomanufacturing with Purolite™ Resins
INSIGHTS
Resilience is a technology focused CDMO biomanufacturing company addressing complex therapeutics. It has seen that the technology of manufacturing novel medicines hasn't kept pace with the wave of scientific discoveries fueling them.
Ecolab has been a partner to Resilience since 2021, supplying the company with its innovative Purolite™ Resin toolbox for monoclonal antibody purification and continuous product supply during the scale up of a new manufacturing line. The relationship began when the Resilience looked to secure traditional capture and polishing resins from multiple suppliers and found that some vendors had long lead times.
Josh Gordon
Senior Scientist, Resilience
ACTIONS
When selecting a downstream processing partner, the Resilience Process Development team looks for specific criteria. It assesses compliance with quality and safety regulations first and foremost, making its resin suppliers’ reputation in these areas very important.
As the company’s manufacturing strategies evolve, Resilience also needs its supply chain partners to adapt and innovate with them.
Ecolab offered quick lead times at the GMP scale, with samples sent within days of initial conversations, faster than competing resins at the Process Development scale.
OUTCOMES
The Resilience team selected resins from the Ecolab monoclonal antibody purification toolbox including both Praesto ™ Jetted A50 affinity and SP and Q ion exchange resins. Both performed well from a yield and product quality standpoint compared to other resins, with the added advantage of immediate availability.
The toolbox of purification resins was an easy swap out for the traditional resins and required minimal process re-optimization.
Consistency goes hand-in-hand with quality performance, and Resilience observed that Ecolab's jetting technology for resin production helped to ensure uniform particle distribution within batches of resin, resulting in greater lot-to-lot consistency.
High yield and productivity helps improve operations and supports a faster route to market for Resilience’s customers. The company believes better quality equates to more consistency and fewer delays to drug product release, thereby getting medicines to the patients who need them faster.
Beyond the resin, Ecolab's Field Applications Scientists team was proactive in listening to Resilience’s development challenges, and as a result has been diligent in reaching out about augmentations or new products that could help the team’s active and upcoming development needs.
Ecolab met requirements for lead time, security of supply, product performance, and cost efficiencies. These factors combined with Ecolab's personal and responsive approach and expertise is what has led to a successful relationship.